There are over-the-counter options available. Two options are ephedrine tablets and pseudoephedrine. Of course before you look at your options, please consult your physician before switching from Singulair to an OTC medication. This is generally what is in pills like Primatene or the store brand variation. It is a stimulant that is used as a bronchodilator. It is also used for nasal decongestion. This is a good option; however, like with any drug it comes with a few side effects and warnings.
Montelukast demonstrated no evidence of mutagenic or clastogenic activity in the following assays: Teratogenic Effect No teratogenicity was observed in rats and rabbits at doses approximately and times, respectively, the maximum recommended daily oral dose in adults based on AUCs [see Nonclinical Toxicology]. Most of these women were also taking other asthma medications during their pregnancy. Nursing Mothers Studies in rats have shown that montelukast is excreted in milk.
It is not known if montelukast is excreted in human milk. The efficacy of SINGULAIR for the treatment of seasonal allergic rhinitis in pediatric patients 2 to 14 years of age and for the treatment of perennial allergic rhinitis in pediatric patients 6 months to 14 years of age is supported by extrapolation from the demonstrated efficacy in patients 15 years of age and older with allergic rhinitis as well as the assumption that the disease course, pathophysiology and the drug's effect are substantially similar among these populations.
Efficacy of SINGULAIR in this age group is extrapolated from the demonstrated efficacy in patients 6 years of age and older with asthma and is based on similar pharmacokinetic data, as well as the assumption that the disease course, pathophysiology and the drug's effect are substantially similar among these populations. Efficacy in this age group is supported by exploratory efficacy assessments from a large, well-controlled safety study conducted in patients 2 to 5 years of age.
Efficacy of SINGULAIR in this age group is extrapolated from the demonstrated efficacy in patients 6 years of age and older with asthma based on similar mean systemic exposure AUC , and that the disease course, pathophysiology and the drug's effect are substantially similar among these populations, supported by efficacy data from a safety trial in which efficacy was an exploratory assessment. The safety of SINGULAIR 4-mg and 5-mg chewable tablets in pediatric patients aged 2 to 14 years with allergic rhinitis is supported by data from studies conducted in pediatric patients aged 2 to 14 years with asthma.
The safety of SINGULAIR 4-mg oral granules in pediatric patients as young as 6 months of age with perennial allergic rhinitis is supported by extrapolation from safety data obtained from studies conducted in pediatric patients 6 months to 23 months of age with asthma and from pharmacokinetic data comparing systemic exposures in patients 6 months to 23 months of age to systemic exposures in adults. The safety and effectiveness in pediatric patients below the age of 12 months with asthma, 6 months with perennial allergic rhinitis, and 6 years with exercise-induced bronchoconstriction have not been established.
Growth Rate in Pediatric Patients A week, multi-center, double-blind, randomized, active- and placebo-controlled parallel group study was conducted to assess the effect of SINGULAIR on growth rate in patients with mild asthma, aged 6 to 8 years.
For each subject, a growth rate was defined as the slope of a linear regression line fit to the height measurements over 56 weeks. No overall differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out.
The pharmacokinetic profile and the oral bioavailability of a single mg oral dose of montelukast are similar in elderly and younger adults. The plasma half-life of montelukast is slightly longer in the elderly. No dosage adjustment in the elderly is required. In the event of overdose, it is reasonable to employ the usual supportive measures; e.
These include reports in adults and children with a dose as high as mg. The clinical and laboratory findings observed were consistent with the safety profile in adults and pediatric patients. There were no adverse experiences in the majority of overdosage reports.
The most frequently occurring adverse experiences were consistent with the safety profile of SINGULAIR and included abdominal pain, somnolence , thirst, headache, vomiting and psychomotor hyperactivity. It is not known whether montelukast is removed by peritoneal dialysis or hemodialysis. These eicosanoids bind to cysteinyl leukotriene CysLT receptors. The CysLT type-1 CysLT1 receptor is found in the human airway including airway smooth muscle cells and airway macrophages and on other pro -inflammatory cells including eosinophils and certain myeloid stem cells.
CysLTs have been correlated with the pathophysiology of asthma and allergic rhinitis. In asthma, leukotriene-mediated effects include airway edema, smooth muscle contraction, and altered cellular activity associated with the inflammatory process. In allergic rhinitis , CysLTs are released from the nasal mucosa after allergen exposure during both earlyand late-phase reactions and are associated with symptoms of allergic rhinitis.
Asthma that is not treated can lead to increased lung damage. If you have allergies, their symptoms may not be reduced. And exercise-related breathing problems may not be controlled. Your medication may not work as well. If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include: They treat serious swelling, skin irritation and breathing difficulty. Corticosteroids can be administered in a pill, in a shot or intravenously. Herbs According to the University of Maryland Medical Center, herbs can alleviate many of the symptoms that Singulair treats.
However they warn that herbs are not as effective, can cause side effects and can interfere with other herbs and drugs. They advise using herbs only under the supervision of a doctor. Herbs known to work on symptoms similar to Singulair include green tea, devil's claw, goldenseal, licorice root and chamomile.
Take as directed Montelukast oral tablet is used for long-term treatment. The clinical and laboratory findings observed were consistent with the safety profile in for and pediatric patients. These are chemicals that trigger an there response in the human body. The relationship between these observations and the clinical benefits of montelukast noted in the clinical trials is not known [see Clinical Studies]. Patients should be instructed to notify their prescriber if these changes occur. And exercise-related breathing problems may not be controlled. Our goal is to provide you with the most relevant and current information. The safety and effectiveness in pediatric patients below the age of 12 months with asthma, 6 months with perennial allergic rhinitis, and 6 years with exercise-induced bronchoconstriction have not been established. Teratogenic Effect No teratogenicity was observed in rats and rabbits at doses approximately and times, respectively, the maximum recommended daily oral dose in adults based on AUCs [see Nonclinical Toxicology]. The pharmacokinetic profile and the oral bioavailability of a single mg oral dose of montelukast are similar in generic and younger adults. In a 4-week, is there a generic for singulair, placebocontrolled clinical study, the safety profile was consistent with that observed in 2-week studies. The pharmacokinetics of montelukast are similar in males and females. Phenylketonuric patients should be informed that the 4-mg and 5-mg chewable tablets contain phenylalanine a component of aspartame. This raises your risk of side effects. Your doctor may start you on a lowered dosage or a different dosing singulair. Montelukast demonstrated no evidence of mutagenic or clastogenic activity in the following assays:
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